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KMID : 0191120130280081248
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Journal of Korean Medical Science
2013 Volume.28 No. 8 p.1248 ~ p.1252
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Imatinib Plasma Monitoring-Guided Dose Modification for Managing Imatinib-Related Toxicities in Gastrointestinal Stromal Tumor Patients
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Yoon Shin-Kyo
Ryu Min-Hee
Yoo Chang-Hoon
Beck Mo-Youl
Ryoo Baek-Yeol
Kang Yoon-Koo
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Abstract
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Imatinib, the first-line treatment in patients with advanced gastrointestinal stromal tumors (GIST), is generally well tolerated, although some patients have difficulty tolerating the standard dose of 400 mg/day. Adjusting imatinib dosage by plasma level monitoring may facilitate management of patients who experience intolerable toxicities due to overexposure to the drug. We present two cases of advanced GIST patients in whom we managed imatinib-related toxicities through dose modifications guided by imatinib plasma level monitoring. Imatinib blood level testing may be a promising approach for fine-tuning imatinib dosage for better tolerability and optimal clinical outcomes in patients with advanced GIST.
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KEYWORD
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Gastrointestinal Stromal Tumors (GIST), Imatinib, Imatinib Plasma Monitoring, Dose-Modification
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